2,843 research outputs found
Multitrace deformations, Gamow states, and Stability of AdS/CFT
We analyze the effect of multitrace deformations in conformal field theories
at leading order in a large N approximation. These theories admit a description
in terms of a weakly coupled gravity dual. We show how the deformations can be
mapped into boundary terms of the gravity theory and how to reproduce the RG
equations found in field theory. In the case of doubletrace deformations, and
for bulk scalars with masses in the range , the deformed
theory flows between two fixed points of the renormalization group, manifesting
a resonant behavior at the scale characterizing the transition between the two
CFT's. On the gravity side the resonance is mapped into an IR non-normalizable
mode (Gamow state) whose overlap with the UV region increases as the dual
operator approaches the free field limit. We argue that this resonant behavior
is a generic property of large N theories in the conformal window, and
associate it to a remnant of the Nambu-Goldstone mode of dilatation invariance.
We emphasize the role of nonminimal couplings to gravity and establish a
stability theorem for scalar/gravity systems with AdS boundary conditions in
the presence of arbitrary boundary potentials and nonminimal coupling.Comment: 14 pages, references added, introduction change
Semi-local quantum liquids
Gauge/gravity duality applied to strongly interacting systems at finite
density predicts a universal intermediate energy phase to which we refer as a
semi-local quantum liquid. Such a phase is characterized by a finite spatial
correlation length, but an infinite correlation time and associated nontrivial
scaling behavior in the time direction, as well as a nonzero entropy density.
For a holographic system at a nonzero chemical potential, this unstable phase
sets in at an energy scale of order of the chemical potential, and orders at
lower energies into other phases; examples include superconductors and
antiferromagnetic-type states. In this paper we give examples in which it also
orders into Fermi liquids of "heavy" fermions. While the precise nature of the
lower energy state depends on the specific dynamics of the individual system,
we argue that the semi-local quantum liquid emerges universally at intermediate
energies through deconfinement (or equivalently fractionalization). We also
discuss the possible relevance of such a semi-local quantum liquid to heavy
electron systems and the strange metal phase of high temperature cuprate
superconductors.Comment: 31 pages, 7 figure
Factors contributing to the temperature beneath plaster or fiberglass cast material
<p>Abstract</p> <p>Background</p> <p>Most cast materials mature and harden via an exothermic reaction. Although rare, thermal injuries secondary to casting can occur. The purpose of this study was to evaluate factors that contribute to the elevated temperature beneath a cast and, more specifically, evaluate the differences of modern casting materials including fiberglass and prefabricated splints.</p> <p>Methods</p> <p>The temperature beneath various types (plaster, fiberglass, and fiberglass splints), brands, and thickness of cast material were measured after they were applied over thermometer which was on the surface of a single diameter and thickness PVC tube. A single layer of cotton stockinette with variable layers and types of cast padding were placed prior to application of the cast. Serial temperature measurements were made as the cast matured and reached peak temperature. Time to peak, duration of peak, and peak temperature were noted. Additional tests included varying the dip water temperature and assessing external insulating factors. Ambient temperature, ambient humidity and dip water freshness were controlled.</p> <p>Results</p> <p>Outcomes revealed that material type, cast thickness, and dip water temperature played key roles regarding the temperature beneath the cast. Faster setting plasters achieved peak temperature quicker and at a higher level than slower setting plasters. Thicker fiberglass and plaster casts led to greater peak temperature levels. Likewise increasing dip-water temperature led to elevated temperatures. The thickness and type of cast padding had less of an effect for all materials. With a definition of thermal injury risk of skin injury being greater than 49 degrees Celsius, we found that thick casts of extra fast setting plaster consistently approached dangerous levels (greater than 49 degrees for an extended period). Indeed a cast of extra-fast setting plaster, 20 layers thick, placed on a pillow during maturation maintained temperatures over 50 degrees of Celsius for over 20 minutes.</p> <p>Conclusion</p> <p>Clinicians should be cautious when applying thick casts with warm dip water. Fast setting plasters have increased risk of thermal injury while brand does not appear to play a significant role. Prefabricated fiberglass splints appear to be safer than circumferential casts. The greatest risk of thermal injury occurs when thick casts are allowed to mature while resting on pillow.</p
Effective AdS/renormalized CFT
For an effective AdS theory, we present a simple prescription to compute the
renormalization of its dual boundary field theory. In particular, we define
anomalous dimension holographically as the dependence of the wave-function
renormalization factor on the radial cutoff in the Poincare patch of AdS. With
this definition, the anomalous dimensions of both single- and double- trace
operators are calculated. Three different dualities are considered with the
field theory being CFT, CFT with a double-trace deformation and spontaneously
broken CFT. For the second dual pair, we compute scaling corrections at the UV
and IR fixed points of the RG flow triggered by the double-trace deformation.
For the last case, we discuss whether our prescription is sensitive to the AdS
interior or equivalently, the IR physics of the dual field theory.Comment: 20 pages, 3 figure
SUSY Splits, But Then Returns
We study the phenomenon of accidental or "emergent" supersymmetry within
gauge theory and connect it to the scenarios of Split Supersymmetry and Higgs
compositeness. Combining these elements leads to a significant refinement and
extension of the proposal of Partial Supersymmetry, in which supersymmetry is
broken at very high energies but with a remnant surviving to the weak scale.
The Hierarchy Problem is then solved by a non-trivial partnership between
supersymmetry and compositeness, giving a promising approach for reconciling
Higgs naturalness with the wealth of precision experimental data. We discuss
aspects of this scenario from the AdS/CFT dual viewpoint of higher-dimensional
warped compactification. It is argued that string theory constructions with
high scale supersymmetry breaking which realize warped/composite solutions to
the Hierarchy Problem may well be accompanied by some or all of the features
described. The central phenomenological considerations and expectations are
discussed, with more detailed modelling within warped effective field theory
reserved for future work.Comment: 29 pages. Flavor and CP constraints on left-right symmetric structure
briefly discussed. References adde
Evolutionary Multi-Objective Design of SARS-CoV-2 Protease Inhibitor Candidates
Computational drug design based on artificial intelligence is an emerging
research area. At the time of writing this paper, the world suffers from an
outbreak of the coronavirus SARS-CoV-2. A promising way to stop the virus
replication is via protease inhibition. We propose an evolutionary
multi-objective algorithm (EMOA) to design potential protease inhibitors for
SARS-CoV-2's main protease. Based on the SELFIES representation the EMOA
maximizes the binding of candidate ligands to the protein using the docking
tool QuickVina 2, while at the same time taking into account further objectives
like drug-likeliness or the fulfillment of filter constraints. The experimental
part analyzes the evolutionary process and discusses the inhibitor candidates.Comment: 15 pages, 7 figures, submitted to PPSN 202
Unbalanced Holographic Superconductors and Spintronics
We present a minimal holographic model for s-wave superconductivity with
unbalanced Fermi mixtures, in 2+1 dimensions at strong coupling. The breaking
of a U(1)_A "charge" symmetry is driven by a non-trivial profile for a charged
scalar field in a charged asymptotically AdS_4 black hole. The chemical
potential imbalance is implemented by turning on the temporal component of a
U(1)_B "spin" field under which the scalar field is uncharged. We study the
phase diagram of the model and comment on the eventual (non) occurrence of
LOFF-like inhomogeneous superconducting phases. Moreover, we study "charge" and
"spin" transport, implementing a holographic realization (and a generalization
thereof to superconducting setups) of Mott's two-current model which provides
the theoretical basis of modern spintronics. Finally we comment on possible
string or M-theory embeddings of our model and its higher dimensional
generalizations, within consistent Kaluza-Klein truncations and brane-anti
brane setups.Comment: 45 pages, 15 figures; v2: two paragraphs below eq. (3.1) slightly
modified, figure 5 (left) replaced, references added; v3: typos corrected,
comments added, figure 12 replace
Components of the Hematopoietic Compartments in Tumor Stroma and Tumor-Bearing Mice
Solid tumors are composed of cancerous cells and non-cancerous stroma. A better understanding of the tumor stroma could lead to new therapeutic applications. However, the exact compositions and functions of the tumor stroma are still largely unknown. Here, using a Lewis lung carcinoma implantation mouse model, we examined the hematopoietic compartments in tumor stroma and tumor-bearing mice. Different lineages of differentiated hematopoietic cells existed in tumor stroma with the percentage of myeloid cells increasing and the percentage of lymphoid and erythroid cells decreasing over time. Using bone marrow reconstitution analysis, we showed that the tumor stroma also contained functional hematopoietic stem cells. All hematopoietic cells in the tumor stroma originated from bone marrow. In the bone marrow and peripheral blood of tumor-bearing mice, myeloid populations increased and lymphoid and erythroid populations decreased and numbers of hematopoietic stem cells markedly increased with time. To investigate the function of hematopoietic cells in tumor stroma, we co-implanted various types of hematopoietic cells with cancer cells. We found that total hematopoietic cells in the tumor stroma promoted tumor development. Furthermore, the growth of the primary implanted Lewis lung carcinomas and their metastasis were significantly decreased in mice reconstituted with IGF type I receptor-deficient hematopoietic stem cells, indicating that IGF signaling in the hematopoietic tumor stroma supports tumor outgrowth. These results reveal that hematopoietic cells in the tumor stroma regulate tumor development and that tumor progression significantly alters the host hematopoietic compartment
The Yangian origin of the Grassmannian integral
In this paper we analyse formulas which reproduce different contributions to
scattering amplitudes in N=4 super Yang-Mills theory through a Grassmannian
integral. Recently their Yangian invariance has been proved directly by using
the explicit expression of the Yangian level-one generators. The specific
cyclic structure of the form integrated over the Grassmannian enters in a
crucial way in demonstrating the symmetry. Here we show that the Yangian
symmetry fixes this structure uniquely.Comment: 26 pages. v2: typos corrected, published versio
Evaluation of diversity among common beans (Phaseolus vulgaris L.) from two centers of domestication using 'omics' technologies
<p>Abstract</p> <p>Background</p> <p>Genetic diversity among wild accessions and cultivars of common bean (<it>Phaseolus vulgaris </it>L.) has been characterized using plant morphology, seed protein allozymes, random amplified polymorphic DNA, restriction fragment length polymorphisms, DNA sequence analysis, chloroplast DNA, and microsatellite markers. Yet, little is known about whether these traits, which distinguish among genetically distinct types of common bean, can be evaluated using omics technologies.</p> <p>Results</p> <p>Three 'omics' approaches: transcriptomics, proteomics, and metabolomics were used to qualitatively evaluate the diversity of common bean from two Centers of Domestication (COD). All three approaches were able to classify common bean according to their COD using unsupervised analyses; these findings are consistent with the hypothesis that differences exist in gene transcription, protein expression, and synthesis and metabolism of small molecules among common bean cultivars representative of different COD. Metabolomic analyses of multiple cultivars within two common bean gene pools revealed cultivar differences in small molecules that were of sufficient magnitude to allow identification of unique cultivar fingerprints.</p> <p>Conclusions</p> <p>Given the high-throughput and low cost of each of these 'omics' platforms, significant opportunities exist for their use in the rapid identification of traits of agronomic and nutritional importance as well as to characterize genetic diversity.</p
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